Healthcare Professionals

Here you will find a collection of scientific journal articles related to the research of medical marijuana.  More articles will be added soon.


Adverse Effects


Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials Real world experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spasticity using tetrahydrocannabinol:cannabidiol (THC:CBD) 
Cannabinoid Hyperemesis Syndrome  
Cannabis and Reversible Cerebral Vasoconstriction Syndrome  
Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review  
Potential Pharmacokinetic Drug-Drug Interactions Between Cannabinoids and Drugs Used For Chronic Pain  
Adverse Effects of Cannabis Scientifically Verified, a World First  







Drug-Drug Interaction

Migraine and Headaches

Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review The Use of Cannabis for Headache Disorders 
Potential Pharmacokinetic Drug-Drug Interactions Between Cannabinoids and Drugs Used For Chronic Pain Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population 
Effects of Cannabis Use on Sedation Requirements for Endoscopic Procedures Short- and Long-Term Effects of Cannabis on Headache and Migraine 


Multiple Sclerosis 


Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial  Persistent cannabis users show neuropsychological decline from childhood to midlife
A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis  Association between Lifetime Marijuana Use and Cognitive Function in Middle Age The Coronary Artery Risk Development in Young Adults (CARDIA) Study
A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis   
Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial   
Effects of THC/CBD oromucosal spray on spasticity-related symptoms in people with multiple sclerosis: results from a retrospective multicenter study   





Cannabinoids for adult cancer-related pain: systematic review and meta-analysis  Cannabis and Pain: A Clinical Review 
An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics  Cannabis and Cannabinoids for Chronic Pain 
Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence  Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials 
Opportunities for cannabis in supportive care in cancer  Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data 
Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy  Cannabis-based medicines for chronic neuropathic pain in adults 
Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study  Smoked cannabis for chronic neuropathic pain: a randomized controlled trial 
Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial



The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial   
Cancer Patients' Experiences With Medical Cannabis-Related Care  



Pregnancy and Breastfeeding


Impact of Medical Marijuana on Pregnant and Lactating Women Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review 
Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk A systematic review of the antipsychotic properties of cannabidiol in humans 
Transfer of Inhaled Cannabis Into Human Breast Milk Exposure to cannabinoids can lead to persistent cognitive and psychiatric disorders 
  The use of medicinal marijuana for posttraumatic stress disorder: a review of the current literature.





Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010 Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome 
Association between medical cannabis laws and opioid overdose mortality has reversed over time Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial 
  Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome 
  Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial 
  Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome




Acute effect of vaporized Cannabis on sleep and electrocortical activity   
No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study   
Cannabis, Cannabinoids, and Sleep: a Review of the Literature   
Cannabidiol in Anxiety and Sleep: A Large Case Series 


Differential Effects of Addictive Drugs on Sleep and Sleep Stages   
Cannabis for restless legs syndrome: a report of six patients   
More evidence of cannabis efficacy in restless legs syndrome   

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